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Treatment and management strategies for semaglutide-associated allodynia The treatment approach for allodynia that develops during semaglutide use depends on what the published evidence shows has worked in documented cases

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Compensation was calculated using FACSDiva software and UltraComp beads (ThermoFisher) stained with indicated antibodies

34(7):723-8 Silvalotti MCA, Yarema MC, Juurlink DN et al

Research suggests the peptide may interact with neurotransmitter systems including the dopaminergic, serotonergic, and GABAergic pathways, though these findings remain in the preclinical stage